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Galvani publications

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  • Alonso, F., Mercadal, B., Salvador, R., Ruffini, G., Bartolomei, F., Wendling, F., Modolo, J., 2023. Biophysical modeling of the electric field magnitude and distribution induced by electrical stimulation with intracerebral electrodes. Biomed Phys Eng Express 9. https://doi.org/10.1088/2057-1976/acd385 

  • Clusella, P., Köksal-Ersöz, E., Garcia-Ojalvo, J., Ruffini, G., 2023. Comparison between an exact and a heuristic neural mass model with second-order synapses. Biol Cybern 117, 5–19. https://doi.org/10.1007/s00422-022-00952-7

  • Galan-Gadea, A., Salvador, R., Bartolomei, F., Wendling, F., Ruffini, G., 2023. Spherical harmonics representation of the steady-state membrane potential shift induced by tDCS in realistic neuron models. J. Neural Eng. 20, 026004. https://doi.org/10.1088/1741-2552/acbabd

  • Simula, S., Garnier, E., Contento, M., Pizzo, F., Makhalova, J., Lagarde, S., Bénar, C.-G., Bartolomei, F., 2023a. Changes in local and network brain activity after stereotactic thermocoagulation in patients with drug-resistant epilepsy. Epilepsia 64, 1582–1593. https://doi.org/10.1111/epi.17613

  • Simula, S., Makhalova, J., Medina Villalon, S., Garnier, E., Ruffini, G., Wendling, F., Bénar, C.-G., Bartolomei, F., 2023b. N°291 – ERC Galvani – Pilot study 2: Impact of transcranial current stimulation on brain networks by simultaneous stereoelectroencephalography recordings in drug-resistant focal epilepsy patients. Clinical Neurophysiology 150, e164. https://doi.org/10.1016/j.clinph.2023.03.273

  • Sanchez-Todo, R., Bastos, A.M., Lopez-Sola, E., Mercadal, B., Santarnecchi, E., Miller, E.K., Deco, G., Ruffini, G., 2023. A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings. NeuroImage 270, 119938. https://doi.org/10.1016/j.neuroimage.2023.119938

  • Daoud, M., Salvador, R., El Youssef, N., Fierain, A., Garnier, E., Biagi, M.C., Medina Villalon, S., Wendling, F., Bénar, C.G., Ruffini, G., Bartolomei, F., 2022. Stereo-EEG based personalized multichannel transcranial direct current stimulation in drug-resistant epilepsy. Clinical Neurophysiology 137, 142–151. https://doi.org/10.1016/j.clinph.2022.02.023

  • Koksal-Ersoz, E., Lazazzera, R., Yochum, M., Merlet, I., Makhalova, J., Mercadal, B., Sanchez-Todo, R., Ruffini, G., Bartolomei, F., Benquet, P., Wendling, F., 2022. Signal processing and computational modeling for interpretation of SEEG-recorded interictal epileptiform discharges in epileptogenic and non-epileptogenic zones. Journal of Neural Engineering 19, 055005. https://doi.org/10.1088/1741-2552/ac8fb4

  • Lopez-Sola, E., Sanchez-Todo, R., Lleal, È., Köksal-Ersöz, E., Yochum, M., Makhalova, J., Mercadal, B., Guasch-Morgades, M., Salvador, R., Lozano-Soldevilla, D., Modolo, J., Bartolomei, F., Wendling, F., Benquet, P., Ruffini, G., 2022. A personalizable autonomous neural mass model of epileptic seizures. J Neural Eng 19. https://doi.org/10.1088/1741-2552/ac8ba8

  • Mercadal, B., Salvador, R., Biagi, M.C., Bartolomei, F., Wendling, F., Ruffini, G., 2022. Modeling implanted metals in electrical stimulation applications. J. Neural Eng. 19, 026003. https://doi.org/10.1088/1741-2552/ac55ae

  • Simula, S., Daoud, M., Ruffini, G., Biagi, M.C., Bénar, C.G., Benquet, P., Wendling, F., Bartolomei, F., 2022. Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects. Frontiers in Neuroscience 16, 909421. https://doi.org/10.3389/fnins.2022.909421

  • Köksal Ersöz, E., Wendling, F., 2021. Canard solutions in neural mass models: consequences on critical regimes. J Math Neurosci 11, 11. https://doi.org/10.1186/s13408-021-00109-z

Selected publications

(click on PI name for more)


Fabrice Wendling

  • Carvallo A, Modolo J, Benquet P, Lagarde S, Bartolomei F, Wendling F. Biophysical Modeling for Brain Tissue Conductivity Estimation Using SEEG Electrodes. IEEE Trans Biomed Eng. 2019

  • Yochum M, Modolo J, Mogul DJ, Benquet P, Wendling F. Reconstruction of post-synaptic potentials by reverse modeling of local field potentials. J Neural Eng. 2019

  • Modolo J, Denoyer Y, Wendling F, Benquet P. Physiological effects of low-magnitude electric fields on brain activity: advances from in vitro, in vivo and in silico models. Curr Opin Biomed Eng. 2018

  • Shamas M, Benquet P, Merlet I, Khalil M, El Falou W, Nica A, Wendling F. On the origin of epileptic High Frequency Oscillations observed on clinical electrodes. Clin Neurophysiol. 2018

  • Mina F, Modolo J, Recher F, Dieuset G, Biraben A, Benquet P, Wendling F. Model-guided control of hippocampal discharges by local direct current stimulation. Sci Rep. 2017

  • Bartolomei F, Lagarde S, Wendling F, McGonigal A, Jirsa V, Guye M, Bénar C. Defining epileptogenic networks: Contribution of SEEG and signal analysis. Epilepsia. 2017

  • Wendling F, Benquet P, Bartolomei F, Jirsa V. Computational models of epileptiform activity. J Neurosci Methods. 2016

  • Wendling F, Gerber U, Cosandier-Rimele D, Nica A, De Montigny J, Raineteau O, Kalitzin S, Lopes da Silva F, Benquet P. Brain (Hyper)Excitability Revealed by Optimal Electrical Stimulation of GABAergic Interneurons. Brain Stimul. 2016

  • Ruffini G, Wendling F, Merlet I, Molaee-Ardekani B, Mekonnen A, Salvador R, Soria-Frisch A, Grau C, Dunne S, Miranda PC. Transcranial current brain stimulation (tCS): models and technologies. IEEE Trans Neural Syst Rehabil Eng. 2013

  • Mina F, Benquet P, Pasnicu A, Biraben A, Wendling F. Modulation of epileptic activity by deep brain stimulation: a model-based study of frequency-dependent effects. Front Comput Neurosci. 2013

  • Merlet I, Birot G, Salvador R, Molaee-Ardekani B, Mekonnen A, Soria-Frish A, Ruffini G, Miranda PC, Wendling F. From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study. PLoS One. 2013

  • Márquez-Ruiz J, Leal-Campanario R, Sánchez-Campusano R, Molaee-Ardekani B, Wendling F, Miranda PC, Ruffini G, Gruart A, Delgado-García JM. Transcranial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits. Proc Natl Acad Sci U S A. 2012

  • Molaee-Ardekani B, Márquez-Ruiz J, Merlet I, Leal-Campanario R, Gruart A, Sánchez-Campusano R, Birot G, Ruffini G, Delgado-García JM, Wendling F. Effects of transcranial Direct Current Stimulation (tDCS) on cortical activity: a computational modeling study. Brain Stimul. 2013

  • Wendling F, Bartolomei F, Mina F, Huneau C, Benquet P. Interictal spikes, fast ripples and seizures in partial epilepsies--combining multi-level computational models with experimental data. Eur J Neurosci. 2012

  • Demont-Guignard S, Benquet P, Gerber U, Biraben A, Martin B, Wendling F. Distinct hyperexcitability mechanisms underlie fast ripples and epileptic spikes. Ann Neurol. 2012

 

Fabrice Bartolomei

  • An S, Bartolomei F, Guye M, Jirsa V. Optimization of surgical intervention outside the epileptogenic zone in the Virtual Epileptic Patient (VEP). PLoS Comput Biol. 2019 Jun 26;15(6):e1007051. doi: 10.1371/journal.

  • Olmi S, Petkoski S, Guye M, Bartolomei F, Jirsa V. Controlling seizure propagation in large-scale brain networks. PLoS Comput Biol. 2019 Feb 25;15(2):e1006805. doi: 10.1371/journal.pcbi.1006800.

  • Proix T, Jirsa VK, Bartolomei F, Guye M, Truccolo W. Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy. Nat Commun. 2018 Mar 14;9(1):1088. doi: 10.1038/s41467-018-02973-y.

  • Besson P, Bandt SK, Proix T, Lagarde S, Jirsa VK, Ranjeva JP, Bartolomei F, Guye M. Anatomic consistencies across epilepsies: a stereotactic-EEG informed high-resolution structural connectivity study. Brain. 2017 Oct
    1;140(10):2639-2652. doi: 10.1093/brain/awx181.

  • Bartolomei F, Lagarde S, Wendling F, McGonigal A, Jirsa V, Guye M, Bénar C. Defining epileptogenic networks: Contribution of SEEG and signal analysis. Epilepsia. 2017 Jul;58(7):1131-1147. doi: 10.1111/epi.13791.

  • Proix T, Bartolomei F, Guye M, Jirsa VK. Individual brain structure and modelling predict seizure propagation. Brain. 2017 Mar 1;140(3):641-654. doi: 10.1093/brain/awx004. PubMed PMID: 28364550;

  • Jirsa VK, Proix T, Perdikis D, Woodman MM, Wang H, Gonzalez-Martinez J, Bernard C, Bénar C, Guye M, Chauvel P, Bartolomei F. The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. Neuroimage. 2017 Jan 15;145(Pt B):377-388.

  • Lagarde S, Buzori S, Trebuchon A, Carron R, Scavarda D, Milh M, McGonigal A, Bartolomei F. The repertoire of seizure onset patterns in human focal epilepsies: Determinants and prognostic values. Epilepsia. 2019 Jan;60(1):85-95. doi: 10.1111/epi.14604.

  • Scavarda D, Cavalcante T, Trébuchon A, Lépine A, Villeneuve N, Girard N, McGonigal A, Milh M, Bartolomei F. Tailored suprainsular partial hemispherotomy: a new functional disconnection technique for stroke-induced refractory epilepsy. J Neurosurg Pediatr. 2018 Dec 1;22(6):601-609.

  • Lagarde S, Roehri N, Lambert I, Trebuchon A, McGonigal A, Carron R, Scavarda D, Milh M, Pizzo F, Colombet B, Giusiano B, Medina Villalon S, Guye M, Bénar CG, Bartolomei F. Interictal stereotactic-EEG functional connectivity in refractory focal epilepsies. Brain. 2018 Oct 1;141(10):2966-2980.
     

Giulio Ruffini

  • Ruffini, Giulio; Salvador, Ricardo; Tadayon, Ehsan; Sanchez-Todo, Roser; Pascual-Leone, Alvaro; Santarnecchi, Emiliano; Realistic modeling of ephaptic fields in the human brain,bioRxiv, 688101,2019, Cold Spring Harbor Laboratory

  • Sanchez-Todo, Roser; Salvador, Ricardo; Santarnecchi, Emiliano; Wendling, Fabrice; Deco, Gustavo; Ruffini, Giulio, Personalization of hybrid brain models from neuroimaging and electrophysiology data,bioRxiv,,461350,2018, Cold Spring Harbor Laboratory

  • Sprugnoli, G; Monti, L; Lippa, L; Neri, F; Mencarelli, L; Ruffini, G; Salvador, R; Oliveri, G; Batani, B; Momi, D; Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation, Science Advances,5,8,eaau9309,2019,American Association for the Advancement of Science

  • Ruffini, Giulio; Wendling, Fabrice; Sanchez-Todo, Roser; Santarnecchi, Emiliano; Targeting brain networks with multichannel transcranial current stimulation (tCS), Current Opinion in Biomedical Engineering, Volume 8, December 2018, Pages 70-77

  • Miranda, Pedro C; Callejón-Leblic, María A; Salvador, Ricardo; Ruffini, Giulio; Realistic modeling of transcranial current stimulation: the electric field in the brain, Current Opinion in Biomedical Engineering,8, 20-27, 2018, Elsevier

  • Neri, Francesco; Mencarelli, Lucia; Menardi, Arianna; Giovannelli, Fabio; Rossi, Simone; Sprugnoli, Giulia; Rossi, Alessandro; Pascual-Leone, Alvaro; Salvador, Ricardo; Ruffini, Giulio; A Novel tDCS Sham Approach Based on Model-Driven Controlled Shunting, Brain Stimulation,,2019, Elsevier

  • Antal, A., et al., Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines., Clin Neurophysiol. 2017 Sep;128(9):1774-1809. doi: 10.1016/j.clinph.2017.06.001.

  • Fischer, David B; Fried, Peter J; Ruffini, Giulio; Ripolles, Oscar; Salvador, Ricardo; Banus, J; Ketchabaw, WT; Santarnecchi, Emiliano; Pascual-Leone, Alvaro; Fox, Michael D; Multifocal tDCS targeting the resting state motor network increases cortical excitability beyond traditional tDCS targeting unilateral motor cortex, Neuroimage, 157,34-44,2017, Elsevier

  • Dagan, Moria; Herman, Talia; Harrison, Rachel; Zhou, Junhong; Giladi, Nir; Ruffini, Giulio; Manor, Brad; Hausdorff, Jeffrey M;  Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease, Movement Disorders,33,4,642-646,2018,Wiley Online Library

  • Fonteneau C, Mondino M, Arns M, Baeken C, Bikson M, Brunoni AR, Burke MJ, Neuvonen T, Padberg F, Pascual-Leone A, Poulet E, Ruffini G, Santarnecchi E, Sauvaget A, Schellhorn K, Suaud-Chagny MF, Palm U, Brunelin J. Sham tDCS: A hidden source of variability? Reflections for further blinded, controlled trials. Brain Stimul. 2019 May - Jun;12(3):668-673. doi: 10.1016/j.brs.2018.12.977.   

  • Ruffini G, Ibañez D, Castellano M, Dubreuil-Vall L, Soria-Frisch A, Postuma R, Gagnon JF, Montplaisir J. Deep Learning With EEG Spectrograms in Rapid Eye Movement Behavior Disorder. Front Neurol. 2019 Jul 30;10:806. doi: 10.3389/fneur.2019.00806. eCollection 2019.  

  • Dubreuil-Vall L, Chau P, Ruffini G, Widge AS, Camprodon JA. tDCS to the left DLPFC modulates cognitive and physiological correlates of executive function in a state-dependent manner. Brain Stimul. 2019 Nov - Dec;12(6):1456-1463. doi: 10.1016/j.brs.2019.06.006. Epub 2019 Jun 6. PubMed PMID: 31221553; PubMed Central PMCID: PMC6851462.

  • Moser J, Bensaid S, Kroupi E, Schleger F, Wendling F, Ruffini G, Preißl H. Evaluating Complexity of Fetal MEG Signals: A Comparison of Different Metrics and Their Applicability. Front Syst Neurosci. 2019 May 27;13:23. doi: 10.3389/fnsys.2019.00023. eCollection 2019. 

  • Ruffini G. An algorithmic information theory of consciousness. Neurosci Conscious. 2017 Oct 12;2017(1):nix019. doi: 10.1093/nc/nix019. eCollection 2017. PubMed PMID: 30042851; PubMed Central PMCID: PMC6007168.

  • Ruffini G, Fox MD, Ripolles O, Miranda PC, Pascual-Leone A. Optimization of multifocal transcranial current stimulation for weighted cortical pattern targeting from realistic modeling of electric fields. Neuroimage. 2014 Apr 1;89:216-25. doi: 10.1016/j.neuroimage.2013.12.002. Epub 2013 Dec 15. 

  • Ruffini G, Wendling F, Merlet I, Molaee-Ardekani B, Mekonnen A, Salvador R, Soria-Frisch A, Grau C, Dunne S, Miranda PC. Transcranial current brain stimulation (tCS): models and technologies. IEEE Trans Neural Syst Rehabil Eng. 2013 May;21(3):333-45. Review. PubMed PMID: 22949089.

  • Miranda PC, Mekonnen A, Salvador R, Ruffini G. The electric field in the cortex during transcranial current stimulation. Neuroimage. 2013 Apr 15;70:48-58. doi: 10.1016/j.neuroimage.2012.12.034. Epub 2012 Dec 27. PubMed PMID: 23274187.

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